EN
TÜRKÇE
Poster - 107
NGAL, CYSTATIN C, ALP, LDH AND ELECTROLYTES AFTER ESWL TREATMENT IN CHILDREN AND ADOLESCENTS WITH UROLITHIASIS
E Milisic*, Z Zvizdic*, A Jonuzi*, N Serdarevic**, L Milisic**
*Clinical center University of Sarajevo, Clinic of pediatric surgery
**Clinical center University of Sarajevo
Introduction: Aim of article was to identify the short-term effects of extracorporeal shock
wave lithotripsy (ESWL) on renal function in children and adolescents with single renal
stones.
Patients and methods: In a 4-year period 30 children were treated for unilateral renal stones
with ESWL. 30 patients (15 boys and 15 girls), met inclusion criteria for the study and
their serum enzymes (alkaline phosphatase, lactate dehydrogenase), cystatin C, serum and
urine electrolytes (sodium, potassium, chloride), and urine neutrophil gelatinase-associated
lipocalin (uNGAL) were tested. Samples were obtained before and on day 1 and day 5
after treatment.
Results: Statistically significant difference was found in the analyzed serum and urine
electrolytes before and after ESWL treatment. Increase of alkaline phosphatase and lactate
dehydrogenase was statistically significant on day 1 after ESWL (p < 0.05) and values
were returned to normal on day 5. Serum cystatin C levels were also significantly
increased during the first four days after ESWL (p < 0.05) and returned to baseline on post-
treatment day 5. There was a statistically significant difference in the levels of uNGAL in
urine before and 24 hours after ESWL (p < 0.05).
Conclusion: On the basis of tests carried out, ESWL is a safe and curative procedure for
the treatment of renal stones in children and adolescents with no evidence of serious
adverse effects on long-term renal function (treatment causes transient functional changes
in renal tubular function in children and adolescents).