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TÜRKÇE
Poster - 23
Quality of life at the age of 6 years in children operated at birth for esophageal atresia
Eugénie Bitoumbou 1, Arnaud Bonnard 2, Alexandre Lapillonne 3, Catherine Jacquier 4, Matthieu Antoine 5, Nicolas Caron 6, Audrey Guinot 7, Thierry Lamireau 8, Sabine Irtan 9, Laure Bridoux-Henno 10, Clémentine Dumant 11, Anne Breton 12, Joséphine Lirussi Borgnon 13, Isabelle Talon 14, Alexandre Fabre 15, Nicoleta Panait 15, Aline Ranke 16, Francesco Laconi 17, Virginie Fouquet 18, Nicolas Kalfa 19, Djamal-Dine Djeddi 20, Stéphanie Willot 21, Claire Dupont 22, Anne Turquet 23, Clara Crémillieux 24, Estelle Darviot 25, Corinne Borderon 26, Olivier Jaby 27, Myriam Pouzac 28, Cécile Pelatan 29, Aurélie Comte 30, Philine De Vries 31, Audrey Nicolas 32, Valérie Triolo 33, Cécilia Tölg 34, Stephan Geiss 35, Laurine Cadart 5, Frédéric Gottrand 5, Madeleine Aumar 5
1 Lille University Hospital, Lille, France
2 University Hospital of APHP Robert Debré, Paris, France
3 University Hospital of APHP Necker-Enfants Malades, Paris, France
4 University Hospital of Grenoble Alpes, Grenoble, France
5 Lille University Hospital, Lille, France
6 University Hospital of HCL Lyon, Lyon, France
7 University Hospital of Nantes, Nantes, France
8 University Hospital of Bordeaux, Bordeaux, France
9 University Hospital of APHP Armand Trousseau, Paris, France
10 University Hospital of Rennes, Rennes, France
11 University Hospital of Rouen, Rouen, France
12 University Hospital of Toulouse, Toulouse, France
13 University Hospital of Dijon, Dijon, France
14 University Hospital of Strasbourg, Strasbourg, France
15 AP-HM University Hospital Centre Marseille
16 University Hospital of Nancy, Nancy, France
17 University Hospital of Reims, Reims, France
18 AP-HP Bicêtre Hospital
19 University Hospital of Montpellier, Montpellier, France
20 University Hospital of Amiens, Amiens, France
21 University Hospital of Tours, Tours, France
22 University Hospital of Caen, Caen, France
23 University Hospital of La Réunion, Saint Denis de la Réunion, France
24 University Hospital of Saint-Etienne, Saint-Etienne, France
25 University Hospital of Angers, Angers, France
26 University Hospital of Clermont-Ferrand, Clermont-Ferrand, France
27 Hospital of Créteil, Créteil, France
28 University Hospital of Orléans, Orléans, France
29 Hospital of Le Mans, Le Mans, France
30 University Hospital of Besançon, Besançon, France
31 University Hospital of Brest, Brest, France
32 University Hospital of Limoges, Limoges, France
33 University Hospital of Nice, Nice, France
34 University Hospital of Fort De France, Martinique, France
35 Hospital of Colmar, Colmar, France
Since esophageal atresia (EA) is a lifelong chronic condition, it may impact on the daily life. This study aimed to assess the quality of life (QoL) at age 6 years in children with EA as reported by children and their parents. Secondary objectives were to evaluate the concordance between child and parent responses, compare QoL in children with pure EA versus other EA types, and identify predictors of impaired QoL.
This prospective, population-based nested-cohort study included data at 6 years of children born between 2010 and 2012 within our national EA registry. QoL was prospectively assessed for both parents and children using the generic PedsQL 4.0 scale.
A total of 230 children were included. At age 6, the median overall QoL score assessed by children was 80/100 (IQR: 69.7–89.2) while the median parental score was 78.4/100 (IQR: 65.0–88.3), with a moderate but significant concordance (intraclass correlation coefficient: 0.47, p<0.05). QoL in children with pure EA was not significantly different from that of other EA types (p=0.52 for children, p=0.75 for parents). Long-term respiratory treatment at age 1 was the only factor significantly associated with impaired QoL (p=0.045). At age 6, respiratory symptoms and at least one respiratory exacerbation in the preceding year were strongly associated with poorer QoL in children (p=0.007 and p=0.017, respectively). Parental assessments further identified respiratory symptoms, exacerbations and orthopedic abnormalities as significant predictors of impaired QoL (p=0.001, p=0.009, and p=0.026, respectively).
Our findings reveal a good overall QoL at age 6 in children with EA, highlighting the effectiveness of adaptive coping strategies developed in the context of a chronic condition from birth. However, respiratory and orthopedic complications remain critical factors influencing QoL and warrant targeted interventions.