EN
TÜRKÇE
Oral Presentation - 34
Nutritional status at the age of 6 years of children operated at birth for oesophageal atresia
E Bitoumbou*, A Bonnard**, A Lapillonne***, M Antoine*, C Jacquier****, N Caron*****, A Guinot******, T Lamireau*******, S Irtan********, L Bridoux-Henno*********, C Dumant**********, A Breton***********, J Lirussi Borgnon************, I Talon*************, A Fabre**************, N Panait**************, A Ranke***************, F Laconi****************, V Fouquet*****************, N Kalfa******************, D Djeddi*******************, S Willot********************, C Dupont*********************, A Turquet**********************, C Crémillieux***********************, E Darviot************************, C Borderon*************************, O Jaby**************************, M Pouzac***************************, C Pelatan****************************, A Comte*****************************, P De Vries******************************, A Nicolas*******************************, V Triolo********************************, C Tölg*********************************, S Geiss**********************************, L Cadart*, F Gottrand*, M Aumar*
*Lille University Hospital, Lille, France
**University Hospital of APHP Robert Debré, Paris, France
***University Hospital of APHP Necker-Enfants Malades, Paris, France
****University Hospital of Grenoble Alpes, Grenoble, France
*****University Hospital of HCL Lyon, Lyon, France
******University Hospital of Nantes, Nantes, France
*******University Hospital of Bordeaux, Bordeaux, France
********University Hospital of APHP Armand Trousseau, Paris, France
*********University Hospital of Rennes, Rennes, France
**********University Hospital of Rouen, Rouen, France
***********University Hospital of Toulouse, Toulouse, France
************University Hospital of Dijon, Dijon, France
*************University Hospital of Strasbourg, Strasbourg, France
**************University Hospital of Marseille, Marseille, France
***************University Hospital of Nancy, Nancy, France
****************University Hospital of Reims, Reims, France
*****************University Hospital of APHP Kremlin Bicêtre, Paris, France
******************University Hospital of Montpellier, Montpellier, France
*******************University Hospital of Amiens, Amiens, France
********************University Hospital of Tours, Tours, France
*********************University Hospital of Caen, Caen, France
**********************University Hospital of La Réunion, Saint Denis de la Réunion, France
***********************Saint Etienne University Hospital Centre
************************University Hospital of Angers, Angers, France
*************************University Hospital of Clermont-Ferrand, Clermont-Ferrand, France
**************************Hospital of Créteil, Créteil, France
***************************University Hospital of Orléans, Orléans, France
****************************Hospital of Le Mans, Le Mans, France
*****************************University Hospital of Besançon, Besançon, France
******************************University Hospital of Brest, Brest, France
*******************************University Hospital of Limoges, Limoges, France
********************************University Hospital of Nice, Nice, France
*********************************University Hospital of Fort De France, Martinique, France
**********************************Hospital of Colmar, Colmar, France
Objectives and study
Due to motility abnormalities and digestive complications, oesophageal atresia (OA) affects food intake and possibly nutritional status. Undernutrition has been shown to affect about 15% of the patients at the age of one year, but the long-term nutritional outcome of these patients remains poorly studied. Our objective was to assess the prevalence and predictive factors of undernutrition and stunting of patients at 6 years old.
Methods
We conducted a prospective, multicentric, nested cohort study. Data of every consecutive patient born in France with OA between 2010 and 2012 were recorded and merged with data collected at birth and 1 year of age in our national registry of OA. Undernutrition and stunting were defined by z-scores of BMI and height-for-age ratio less than -2 standard deviations, respectively. Uni- and multivariate analyses were performed thanks to the imputation of missing data.
Results
We included 449 of the 468 eligible patients (92%). Prevalence of undernutrition and stunting at 6 years was respectively 9.0% and 11.1%. Undernutrition at one year of age was the only independent factor predictive for undernutrition at the age of 6 (OR 4.37 (IC95% 1.77 to 10.77), p=0.002), while being small for gestational age, a congenital heart malformation and preexisting stunting at one year were independent factors predictive for stunting at 6 years (OR 2.32 (IC95% 1.01 to 5.33),p = 0.048, OR 1.99 (IC95% 1.00 to 3.93), p = 0.049; and OR 5.51 (IC95% 2.31 to 13.18), p=0.0002, respectively).
Conclusion
Our study highlights that undernutrition and stunting remain frequent in the middle-term follow-up in OA and originate mainly during the first year of life.