EN
TÜRKÇE
Oral Presentation - 29
High resolution manometry in patients with esophageal atresia: classification and relation with clinical symptoms
M van Lennep*, C Mussies*, R Gorter**, U Krishnan***, M van Wijk*
*Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital Amsterdam UMC, Amsterdam, the Netherlands
**Department of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, Amsterdam, the Netherlands
***Department of Gastroenterology, Sydney Children’s Hospital, Randwick, Australia
Abstract
Background: Various abnormal motility patterns in children with esophageal atresia (EA) have been described using high-resolution manometry (HRM). This study aimed to analyze HRM patterns in EA patients, categorize them by dysmotility severity, and evaluate correlations between EA-related symptoms, comorbidities, and HRM parameters.
Methods: Medical records of EA patients who underwent HRM between 2016 and 2020 were retrospectively reviewed for EA-related symptoms and gastroesophageal reflux disease (GERD). HRM analysis classified the proximal, middle, and distal esophageal segments (defined as the upper 25%, middle 50%, and lower 25% of the esophagus, respectively) based on preserved peristalsis, absent contractions, or present contractions. HRM parameters were calculated using www.swallowgateway.com. Esophageal dysmotility was categorized into four groups based on preserved motility and contraction strength. Spearman’s correlation coefficient (rs) was used to assess associations between HRM findings and EA symptoms.
Results: HRM data from 25 children (median age: 1.9 years) were analyzed. Dysmotility correlated with regurgitation (rs=0.524, p=0.007) and dysphagia (rs=0.437, p=0.029). Negative correlations were observed between proximal motility and regurgitation (rs=-0.506, p=0.010) and dysphagia (rs=-0.646, p=0.000), as well as between distal motility and chest pain (rs=-0.417, p=0.038) and regurgitation (rs=-0.436, p=0.001). Additionally, pharyngeal contractile integral and esophagogastric junction resting pressure negatively correlated with dysphagia (rs=-0.422, p=0.036 and rs=-0.423, p=0.044, respectively).
Conclusions: Dysphagia, chest pain, and regurgitation are associated with specific HRM findings in EA patients. Further prospective studies are needed to explore the clinical implications of these motility patterns.