EN
TÜRKÇE
Poster - 30
Peripheral airway function in adolescents operated for esophageal atresia
V Gatzinsky*, M Dellenmark-Blom**, E Axman***, L Jönsson**
*Department of Pediatric Surgery, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden Institute of Clinical Sciences, Department of Pediatrics, Queen Silvia Children's Hospital, Gothenburg, Sweden
**Department of Pediatric Surgery, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden Institute of Clinical Sciences, Department of Pediatrics, Queen Silvia Children's Hospital, Gothenburg, Sweden
***The Queen Silva Children’s Hospital, Department of Pediatric Surgery, Gothenburg, Sweden
Introduction: Pulmonary function might be affected in patients operated for esophageal atresia (EA). Little is known about the effects on the peripheral airways among adolescents operated for EA. We wanted to describe the prevalence of peripheral airway pathology in adolescents with EA.
Method: An 8 year prospective data collection of pulmonary function at 15-16 years in patients born with EA operated at a tertiary center between 2001-08 was undertaken as part of the local follow up program. Patients primary operated outside the geographical catchment area as well as patients with genetic deviations were excluded. The peripheral airway pathology was determined using multiple breath washout (MBW) with SF6 measuring the lung clearence index (LCI). The Global Lung Function Initiative reference values were used for calculating z-scores. The study was approved by the Swedish Ethical Review Authority (refnr 408-16).
Result: A total of 61 patients, 32 boys, were included. Mean gestational age was 37 weeks, mean birthweight 2640 g. Forty-nine had EA Gross type C, 6 type A, 3 type B and 3 type E. Fifty-one (84%) of the patients underwent a MBW with SF6 at a mean age of 15,2 (SD 0,4) year. LCI was mean 6,72 (SD 0,77) and 12/51 (24%) had a z-score > 2, of whom 10 had Gross type C and two had type A.
Conclusion: This study suggests that a subgroup of adolescents aged 15-16 years with EA have peripheral airway dysfunction. The reason is not known but will be further investigated. Such further studies will be important to raise awareness of the issue and hopefully find ways to optimize the pulmonary function in patients operated for EA.